OpenCRAVAT Chain
Decentralized Genomic Annotation Network
Democratizing Precision Medicine Through Blockchain
Prepared for Dr. Rachel Karchin
The Vision
A world where genomic annotation is accessible, sustainable, and community-driven
Privacy First
Genomes remain confidential and owned by individuals & families
Global Access
Democratized annotation tools available to researchers worldwide
Gamified Science
Token incentives attract young scientists to contribute
Sustainable
Self-sustaining through tokenomics and community participation
Decentralized Node Network
Each node processes VCF files locally • Results tokenized on Story Protocol • Privacy preserved
CRAVAT Token Economics
Incentivizing participation through tokenized rewards
Run Node
Host OpenCRAVAT instance
Process VCFs
Annotate genomic data
Submit to ClinVar
Share variant interpretations
Token Utility
• Priority job processing • Access to premium annotators
• Governance voting rights • Trading on DEX platforms
• Staking for increased rewards • Access to AI interpretation tools
GenoBank's OpenCRAVAT Innovations
🔐 Web3 Authentication
Replaced email/password with wallet signatures. Users control their genomic data through blockchain identities.
⛓️ Story Protocol Integration
Every annotation job becomes a BioIP NFT. Creates immutable audit trail and enables IP licensing.
🤖 Claude AI Interpretation
AI-powered variant analysis. Helps clinicians understand complex genomic data through natural language.
🏆 ClinVar Incentives
[Coming Soon]
Token rewards for community submissions. Outpace privatized databases like Genomenon.
Community Incentive Matrix
🏃 Node Operators
- ✓ Base rewards for uptime
- ✓ Bonus for job completion speed
- ✓ Multiplier for geographic diversity
👩🔬 Researchers
- ✓ Free annotations for contributions
- ✓ Rewards for variant curation
- ✓ Bonuses for rare variant discovery
🏥 Clinical Labs
- ✓ Priority processing lanes
- ✓ Bulk annotation discounts
- ✓ Custom annotator access
🎮 Gen Z Scientists
- ✓ Gamified leaderboards
- ✓ NFT achievement badges
- ✓ Social recognition system
"Making genomic annotation as engaging as DeFi yield farming"
Implementation Roadmap
Phase 1: Foundation (Q1 2025)
In Progress✓ Web3 authentication system deployed
✓ Story Protocol integration complete
✓ Claude AI interpretation active
→ Deploy first 5 partner nodes
Phase 2: Token Launch (Q2 2025)
Upcoming• Launch CRAVAT token on Ethereum/Polygon
• Implement node reward system
• Open testnet for community nodes
• ClinVar submission portal with rewards
Phase 3: Scale (Q3-Q4 2025)
Future• 100+ global nodes target
• DAO governance implementation
• Cross-chain bridges (BSC, Solana)
• Mobile app for variant submission
Phase 4: Ecosystem (2026)
Future• Integrate with major EHR systems
• Research grant funding via DAO
• Educational programs with token rewards
• Global hackathons and challenges
Join the Revolution
Together, we can democratize genomic annotation and advance precision medicine for all humanity.
Why Johns Hopkins Should Lead
• Pioneer status in decentralized genomics
• Sustainable funding through tokenomics
• Global community of contributors
• Outpace commercial competitors ethically
• Train next generation with Web3 skills
Contact: Daniel Uribe, CEO GenoBank.io
[email protected] | Together with Dr. Rachel Karchin