/* GenoBank.io whitepaper house style. Source: erc-8356 / humanmark. */
*, *::before, *::after { margin: 0; padding: 0; box-sizing: border-box; }
        :root {
            --white: #ffffff;
            --black: #000000;
            --orange: #f39240;
            --blue: #001fff;
            --light-gray: #f7f7f7;
            --border-gray: #e5e5e5;
            --text-body: #000000;
            --text-muted: #444444;
            --code-bg: #f4f4f4;
            --green: #18a34a;
            --max-width: 860px;
        }
        html { scroll-behavior: smooth; }
        body {
            font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, "Helvetica Neue", Arial, sans-serif;
            background: var(--white);
            color: var(--text-body);
            font-size: 16px;
            line-height: 1.75;
        }
        @media print {
            .sidebar { display: none; }
            .main-content { margin-left: 0; }
            a { color: var(--black); text-decoration: none; }
            .mermaid-container { page-break-inside: avoid; }
        }
        .sidebar {
            position: fixed; left: 0; top: 0; width: 280px; height: 100vh;
            background: var(--light-gray); border-right: 1px solid var(--border-gray);
            overflow-y: auto; z-index: 100; padding: 24px 0 40px;
        }
        .sidebar-logo { padding: 0 20px 20px; border-bottom: 1px solid var(--border-gray); margin-bottom: 16px; }
        .sidebar-logo img { width: 140px; height: auto; display: block; }
        .sidebar-label {
            font-size: 10px; letter-spacing: 0.12em; text-transform: uppercase;
            color: var(--text-muted); font-weight: 600; padding: 0 20px; margin-bottom: 6px; margin-top: 16px;
        }
        .sidebar-nav a {
            display: block; font-size: 12.5px; color: var(--text-body); text-decoration: none;
            padding: 5px 20px; border-left: 3px solid transparent; line-height: 1.35;
        }
        .sidebar-nav a:hover, .sidebar-nav a.active { border-left-color: var(--orange); background: var(--border-gray); }
        .sidebar-back { display: block; font-size: 12px; color: var(--text-muted); text-decoration: none; padding: 8px 20px; margin-bottom: 8px; }
        .sidebar-back:hover { color: var(--orange); }
        .main-content { margin-left: 280px; padding: 0 40px 80px; }
        .cover { max-width: var(--max-width); margin: 0 auto; padding: 60px 0 50px; border-bottom: 2px solid var(--border-gray); }
        .cover-logo { width: 180px; height: auto; display: block; margin-bottom: 36px; }
        .cover-label { font-size: 11px; letter-spacing: 0.15em; text-transform: uppercase; color: var(--orange); font-weight: 700; margin-bottom: 12px; }
        .cover-title { font-size: 2.4rem; font-weight: 800; line-height: 1.15; color: var(--black); margin-bottom: 18px; }
        .cover-subtitle { font-size: 1.15rem; line-height: 1.55; color: var(--text-muted); margin-bottom: 28px; max-width: 42em; }
        .cover-meta { display: grid; grid-template-columns: 1fr 1fr; gap: 10px 24px; margin-bottom: 28px; font-size: 14px; }
        .cover-meta-item strong { display: block; font-size: 10px; letter-spacing: 0.1em; text-transform: uppercase; color: var(--text-muted); margin-bottom: 2px; }
        .stats-row { display: grid; grid-template-columns: repeat(4, 1fr); gap: 12px; margin-top: 24px; }
        .stat-card { background: var(--light-gray); border: 1px solid var(--border-gray); border-top: 3px solid var(--orange); padding: 14px 12px; text-align: center; }
        .stat-card .stat-value { font-size: 1.35rem; font-weight: 800; color: var(--black); line-height: 1.15; }
        .stat-card .stat-label { font-size: 10px; letter-spacing: 0.06em; text-transform: uppercase; color: var(--text-muted); margin-top: 4px; }
        .article { max-width: var(--max-width); margin: 0 auto; }
        .abstract-box { background: var(--light-gray); border-left: 4px solid var(--blue); padding: 28px 32px; margin: 40px 0; }
        .abstract-box h2 { font-size: 11px; letter-spacing: 0.12em; text-transform: uppercase; color: var(--blue); margin-bottom: 12px; font-weight: 700; }
        .section-heading { font-size: 1.55rem; font-weight: 700; margin: 56px 0 18px; padding-bottom: 8px; border-bottom: 2px solid var(--border-gray); color: var(--black); }
        .section-heading .section-num { color: var(--orange); margin-right: 6px; }
        h3 { font-size: 1.15rem; font-weight: 700; margin: 32px 0 10px; color: var(--black); }
        p { margin-bottom: 16px; color: var(--text-body); }
        a { color: var(--blue); text-decoration: none; }
        a:hover { text-decoration: underline; }
        ul, ol { margin: 12px 0 18px 22px; }
        li { margin-bottom: 6px; color: var(--text-body); }
        ul li::marker { color: var(--orange); }
        code { font-family: "SF Mono", "Fira Code", Consolas, Monaco, monospace; font-size: 0.88em; background: var(--code-bg); border: 1px solid var(--border-gray); padding: 1px 5px; border-radius: 3px; color: var(--black); }
        pre { background: var(--code-bg); border: 1px solid var(--border-gray); border-left: 4px solid var(--orange); padding: 20px 24px; overflow-x: auto; margin: 20px 0 24px; border-radius: 2px; }
        pre code { background: none; border: none; padding: 0; font-size: 13px; line-height: 1.6; }
        .mermaid-container { margin: 28px 0; border: 1px solid var(--border-gray); background: var(--white); }
        .mermaid-label { font-size: 11px; letter-spacing: 0.1em; text-transform: uppercase; color: var(--text-muted); background: var(--border-gray); padding: 6px 16px; font-weight: 600; }
        .mermaid-container .mermaid { padding: 24px; display: flex; justify-content: center; }
        .mermaid { background: #fafafa; padding: 20px; border-radius: 8px; margin: 0; overflow-x: auto; }
        .table-wrapper { overflow-x: auto; margin: 20px 0 28px; }
        table { width: 100%; border-collapse: collapse; font-size: 14px; }
        thead { background: var(--black); color: var(--white); }
        thead th { padding: 10px 14px; text-align: left; font-size: 11px; letter-spacing: 0.08em; text-transform: uppercase; font-weight: 600; }
        tbody tr:nth-child(odd) { background: var(--light-gray); }
        tbody tr:nth-child(even) { background: var(--white); }
        tbody td { padding: 9px 14px; border-bottom: 1px solid var(--border-gray); vertical-align: top; color: var(--black); }
        .callout { padding: 18px 22px; margin: 24px 0; border-radius: 1px; }
        .callout-principle { background: #f0f4ff; border-left: 4px solid var(--blue); }
        .callout-warning { background: #fff5ec; border-left: 4px solid var(--orange); }
        .callout-result { background: #f0fff4; border-left: 4px solid var(--green); }
        .callout-critical { background: #fff0f0; border-left: 4px solid #cc0000; }
        .callout-label { font-size: 10px; letter-spacing: 0.12em; text-transform: uppercase; font-weight: 700; margin-bottom: 6px; }
        .callout-principle .callout-label { color: var(--blue); }
        .callout-warning .callout-label { color: var(--orange); }
        .callout-result .callout-label { color: var(--green); }
        .callout-critical .callout-label { color: #cc0000; }
        .callout p { margin: 0; font-size: 14.5px; line-height: 1.7; color: var(--black); }
        .callout p + p { margin-top: 10px; }
        .footer-note { max-width: var(--max-width); margin: 60px auto 0; padding-top: 24px; border-top: 1px solid var(--border-gray); font-size: 13px; color: var(--text-muted); }
        
        .status-banner {
            margin: 18px 0 0; padding: 12px 16px; font-size: 13.5px; line-height: 1.5;
            background: #fff5ec; border: 1px solid #f39240; border-left: 4px solid #f39240; color: #000000;
        }
        .status-banner strong { font-weight: 700; }
        .figure-alt {
            font-size: 13px; line-height: 1.55; color: #000000; background: #f7f7f7;
            border-top: 1px solid #e5e5e5; padding: 12px 16px; margin: 0;
        }
        .figure-alt strong { font-size: 10px; letter-spacing: 0.1em; text-transform: uppercase; color: #444444; display: block; margin-bottom: 4px; }
        .related-box {
            margin: 40px 0; padding: 22px 24px; border: 1px solid #e5e5e5; background: #f7f7f7;
            border-left: 4px solid #001fff;
        }
        .related-box h2 {
            font-size: 11px; letter-spacing: 0.12em; text-transform: uppercase; color: #001fff;
            margin-bottom: 12px; font-weight: 700;
        }
        .related-box ul { margin: 0 0 0 18px; }
        .related-box li { margin-bottom: 8px; font-size: 14.5px; }
        .checklist {
            margin: 24px 0; padding: 20px 22px; border: 1px solid #e5e5e5; background: #f0fff4;
            border-left: 4px solid #18a34a;
        }
        .checklist h3 { margin-top: 0; font-size: 1.05rem; }
        .checklist ol { margin: 10px 0 0 20px; }
        .checklist li { margin-bottom: 8px; font-size: 14.5px; }
        .cite-box {
            margin: 28px 0; padding: 16px 18px; background: #f7f7f7; border: 1px solid #e5e5e5;
            font-size: 13.5px; line-height: 1.55;
        }
        .cite-box strong { font-size: 10px; letter-spacing: 0.1em; text-transform: uppercase; color: #444444; display: block; margin-bottom: 6px; }
        @media print {
            .status-banner { break-inside: avoid; }
            .checklist, .related-box, .cite-box { break-inside: avoid; }
            .figure-alt { color: #000 !important; }
        }

        @media (max-width: 900px) {
            .sidebar { display: none; }
            .main-content { margin-left: 0; padding: 0 20px 60px; }
            .cover-title { font-size: 1.8rem; }
            .stats-row { grid-template-columns: repeat(2, 1fr); }
            .cover-meta { grid-template-columns: 1fr; }
        }