Technical research and architecture documentation covering blockchain genomics, BioIP protocol, and decentralized biodata infrastructure.
A practical guide to self-directed mRNA cancer immunotherapy for patients who want to take control of their treatment. Step-by-step instructions for retaining your tumor tissue, getting it sequenced, identifying your neoantigens, finding a CDMO to manufacture your personalized vaccine, and navigating regulatory pathways like Right to Try. Includes cost breakdown ($30K-80K) and timeline (8-12 weeks).
Read Guide →This whitepaper presents a patient co-ownership model enabled by Biosample NFT (BioNFT) technology—blockchain-based digital tokens that establish verifiable chain of custody, encode revocable consent, and preserve patient sovereignty from biopsy through vaccine delivery. Demonstrates the technical feasibility and regulatory pathways for enabling individual patients to retain ownership of their neoantigen sequences while accessing GMP-grade mRNA manufacturing through CDMO partnerships. Creates a parallel pathway for patients who choose to exercise sovereignty over their own biology.
Read Whitepaper →A public database and protocol for shared cancer neoantigen sequences derived from common driver mutations (KRAS G12D, BRAF V600E, TP53 hotspots). Unlike private patient-specific neoantigens, shared neoantigens from hotspot mutations are identical across all patients and can be pre-computed, validated, and made freely available. Defines the data architecture, HLA-peptide binding matrices, pre-designed mRNA sequences, and Story Protocol attribution layer enabling a public commons for cancer vaccine development.
Read Whitepaper →A comprehensive proposal for blockchain-based orchestration of GA4GH Passport 2.0 using Cosmos SDK. Maps GA4GH concepts to blockchain primitives: Data Passports → Biosample NFTs (consent tokens with DUO codes), Researcher Passports → Soulbound identity tokens, Data Visas → On-chain ControlledAccessGrants (DAC approvals), and Policy Engine → Smart Contracts (automated DUO code matching). Proposes Broad Institute Consortia Blockchain with validator governance, self-sovereign identity for researchers and patients, immutable audit trails, and backward compatibility with AAI 1.2. Includes detailed Cosmos SDK module design, migration path, and comparison with centralized approaches. Draft for GA4GH DSWS review.
Read Whitepaper →A comprehensive technical specification for BioFS Protocol—a blockchain-based system for federated genomic data discovery using cryptographic fingerprints, dual-chain NFT minting, and automated laboratory onboarding.
Read Whitepaper →A comprehensive whitepaper addressing the clinical trial data loss crisis through patient-owned genomic data vaults secured by blockchain technology. Using HER2-positive breast cancer trials for Enhertu development as a case study, this paper demonstrates how patient-controlled infrastructure enables longitudinal research, cross-institutional collaboration, and ethical data reuse while preserving patient autonomy, attribution, and economic participation. Features the GenoVault architecture combining BioFS Protocol for federated data discovery and x402 BioData Router for cryptographic consent management.
Read Whitepaper →A novel architecture combining Coinbase's x402 HTTP-native payment protocol with Story Protocol's Programmable IP Licensing framework to create a patient-centric, cross-lab genomic analysis network. Demonstrates complete 5-step pipeline from FASTQ to clinical reports with Byzantine-fault-tolerant quality assurance.
Read Whitepaper →A comprehensive technical specification for Sequentia Network (Chain ID: 15132025)—a specialized Layer-1 blockchain designed for genomic data federation, bioinformatics computation, and programmable licensing, featuring BioData Router smart contract, BioFS Protocol, LabNFTs, BioNFTs, Story Protocol integration, and partner chains including OpenCRAVAT, AlphaGenome, SOMOS DAO, AlphaFold, and Claude AI.
Read Whitepaper →